中文名 | SPD304 dihydrochloride |
英文名 | SPD304 dihydrochloride |
别名 | 化合物 T12985 |
英文别名 | TNF-α inhibitor SPD304 dihydrochloride |
CAS | 1049741-03-8 |
化学式 | C32H33ClF3N3O2 |
分子量 | 584.08 |
存储条件 | -20°C,干燥,密封 |
外观 | 白色粉末固体。 |
MDL号 | MFCD09265259 |
体外研究 | SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation. |
体内研究 | SPD304 cannot be used in vivo due to its high toxicity. |
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